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Signs of serotonin syndrome

Easily annoyed, Delirium, Reduction of consciousness, Fits, Restlessness, Increased middle rate, Perspiration, Shivering, Tremor, Mental status changes, Restlessness, Increased reflexes, Increased reflexes, Stiffness, Shaking, Pain in the abdomen, Diarrhea, Perspiration, Increased heat, High blood pressure. All these tend to be signs of serotonin syndrome. Just about all can come generally in the first 24 hours following taking an o.d. of serotonin drugs. This signs or symptoms tend to be on cognitive stage, autonomic level and somatic level. Serotonin Syndrome look usually following overdose of serotonin drugs as well as drug combination that increase synaptic serotonin. Drugs which are understand to stimulate high levels of serotonin are: MAOIs, TCAs, SSRIs, SNRIs, Bupropion, Tramadol, Fentany, Oxycodone, Hydrocodone, MDMA, MDA, Amphetamine, Sibutramine, Crack, Triptans, LSD, Panax Ginseg, Nutmed, Yohimbe, Syrian Rue, Ritonavir, Granisetron, Olanzapine, Valproate, Buspirone, Lithium, Linezolid, Dextromethorphan, Risperidone, Trypthophan, L-Dopa, Valproate, Pep pill. Due to the fact serotonin toxicity it's certainly not tested in the laboratory for diagnosis, symptoms tend to be the one that need seen. The best set of criteria to use to diagnose serotonin toxicity is Hunter Serotonin Toxicity Criteria.

Treatment for serotonin syndrome tend to be as follows: discontinuing drugs which made the overdose posible and also drugs that can contribute administration of serotonin antagonist (eg. cyproheptadine) for cut cases of toxicity for agitation, muscle mass stiffness and seizure like movements, benzodiazepines (Valium, Ativan) Intra venous fluids Considering that serotonin syndrome is not simple to diagnose, prevention is needed for any serotonin drugs mixture of that will cause serotonin toxicity.

Dunkley, EJ, Isbister, GK, Sibbritt, D, Dawson, AH, Whyte, IM, The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity, QJM 2003; 96:635-642 Prator BC. Serotonin syndrome. J Neurosci Nurs. 2006 Apr;38(2):102-5. Ford MD, Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:150, 522, 547, 550.